HGH Somatropin

HGH Somatropin

HGH is a sterile, non-pyrogenic white lyophilised powder intended for subcutaneous or intramuscular injection after reconstitution with bacteriostatic water. Widely recognised for its role in growth and metabolism, HGH is used in medical and therapeutic settings to treat growth hormone deficiency (GHD) and promote tissue recovery.

🔬 Pharmacology & Mechanism of Action

Human Growth Hormone (Somatropin) is therapeutically equivalent to naturally occurring pituitary HGH. It stimulates linear growth in children with GHD and helps normalise Insulin-like Growth Factor-I (IGF-I) levels. In adults, it contributes to:

Reduced fat mass

Increased lean body mass

Improved lipid metabolism

Restoration of IGF-I levels

⚙️ Pharmacokinetics

Absorption: After a 4 mg subcutaneous injection in healthy adults, the AUC is 291 hr·μg/L and peak levels reach 37 μg/L.

Distribution: Average volume of distribution is 1.4 L/kg.

Metabolism: Presumed to follow regular protein breakdown in the liver and kidneys.

Excretion: Average clearance is 0.23 L/hr/kg, with a half-life of ~2.4 hours.

💉 Indications & Usage HGH is indicated for:

Long-term treatment of pediatric growth failure due to inadequate endogenous GH secretion.

Replacement therapy in adults with GHD, either from childhood or adult onset (confirmed by GH stimulation test).

📏 Dosage & Administration

Pediatric: 0.16 to 0.24 mg/kg/week, divided into daily evening injections.

Adults: Start with ≤ 0.04 mg/kg/week, titrated up to 0.08 mg/kg/week as needed.

Injection sites: Thigh, buttocks, abdomen – rotate sites to avoid lipoatrophy.

🚫 Contraindications

Active neoplastic (cancerous) activity

Patients with intracranial tumours must complete treatment before starting HGH.

Discontinue immediately if tumour growth is detected.

⚠️ Warnings

Contains benzyl alcohol – not safe for newborns.

Should be used cautiously in patients with acute critical illness (e.g. post-surgery, trauma, or respiratory failure).

Not studied sufficiently in pregnant, nursing, or elderly populations — use with caution.

💊 Drug Interactions

Glucocorticoids may inhibit HGH's growth effects.

HGH can alter liver metabolism (cytochrome P450 enzymes), affecting other drugs like corticosteroids, anticonvulsants, sex hormones, etc. Close monitoring is advised when used in combination.

👶 Use in Pregnancy and Nursing

Category B: Animal studies show no harm, but no adequate human studies exist.

Not known whether HGH is excreted in breast milk — use caution during lactation.

🧓 Geriatric Use

It has not been studied thoroughly in people over 65.

The elderly may be more sensitive to HGH and may experience more side effects.

❗ Adverse Effects

Common side effects include:

Injection site reactions (redness, swelling, numbness)

Fluid retention (swelling, joint stiffness)

Muscle and joint pain

Carpal tunnel syndrome (mostly in adults)

Benign intracranial hypertension

Disturbances in glucose metabolism (including rare cases of diabetes)

Rare but serious:

Lipoatrophy at repeated injection sites

Leukaemia (reported in a small number of treated children; link unclear)

🏋️ Abuse in Sports

Warning: Misuse of HGH for performance enhancement is not advised.

This product is for medical use only and should be administered under proper medical supervision. Cooper Pharma disclaims responsibility for any off-label or unsupervised usage.